讲座题目: Imaging veins, oxygen extraction fraction,  arteries, vessel wall and macromolecular transport using susceptibility  weighted imaging (SWI) and mapping (SWIM)

主讲人: Prof. E. Mark Haacke

开始时间: 2014-12-09 13:30

讲座地址: 中北校区老图书馆二楼会议室

报告人简介：

E. Mark Haacke is a pioneer of MR angiographic imaging, fast imaging,  super-resolution image reconstruction, coronary artery imaging and  Susceptibility Weighted Imaging (SWI).  His research has focused on  studying the role of magnetic field variations in the human body and  applying the results to clinical translational research. MRA and SWI  have both become powerful tools in the arsenal of MR methods.  Super-resolution reconstruction may also prove an important concept in  the more recent efforts of compressed sensing image reconstruction to  allow for faster imaging. Dr. Haacke is also the author of Magnetic  Resonance Imaging: Physical Principles and Sequence Design. He has  trained more than 100 students, post-doctoral fellows, young faculty and  researchers over the last 30 years. Despite the growth of MRI and its  maturity, he remains as excited about its potential today as when he  first started and refers to MRI as a field that is “SEMPER INCITARE” or  “always exciting”.

报告简介😏：
 Some of the key problems today in imaging relate to quantification.
 Our interests lie in the use of susceptibility weighted imaging (SWI) to  study neurovascular diseases such as dementia, multiple sclerosis,  Parkinson’s disease, stroke and traumatic brain injury. SWI provides  exquisite images of iron content in the form of deoxyhemoglobin,  ferritin and microbleeds. However, it is not quantitative. Today a new  approach that uses the phase from SWI data called quantitative  susceptibility mapping (QSM) or susceptibility weighted imaging and  mapping (SWIM) provides a practical way to quantify the iron content.  Although SWI has been used successfully to image veins for nearly 20  years now, imaging arteries has not been possible because the arteries  have a similar susceptibility to the surrounding tissue. However, by  introducing an iron based contrast agent one could imagine effectively  turning arteries into veins, thereby opening the door to unprecedented  high resolution imaging of the arterial system.
 We call this “Microvascular In-vivo Contrast Revealed Origins” of MICRO  imaging for short. The ramifications would be a much better means to  study the microvascular system and how its breakdown is inherent in  different diseases. We also show that both SWI and MRA can be married  into a single scan allowing for a more complete picture of the  vasculature. Finally, marrying perfusion weighted imaging with SWI and  SWIM allows for a full study of the brain’s hemodynamics. Methods like  SWI which require high resolution in many cases are ideal candidates for  applications to fast imaging methods such as data extrapolation,  super-resolution and compressed sensing.